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Review
. 2014 Nov:23:64-8.
doi: 10.1016/j.dnarep.2014.08.005. Epub 2014 Sep 29.

The function of nicotinamide phosphoribosyltransferase in the heart

Chiao-Po Hsu  1 , Takanobu Yamamoto  2 , Shinichi Oka  2 , Junichi Sadoshima  3
Affiliations
Review

The function of nicotinamide phosphoribosyltransferase in the heart

Chiao-Po Hsu et al. DNA Repair (Amst). 2014 Nov.

Abstract

In addition to its roles as a coenzyme and an electron transfer molecule, nicotinamide adenine dinucleotide (NAD+) has emerged as a substrate of sirtuins, a family of enzymes that control aging and metabolism. Nicotinamide phosphoribosyltransferase (Nampt), a rate-limiting enzyme in the NAD+ salvage pathway, plays an important role in controlling the level of NAD+ and the activity of Sirt1 in the heart and the cardiomyocytes therein. Nampt protects the heart from ischemia and reperfusion injury by stimulating Sirt1. In this review, we summarize what is currently known regarding the function of Nampt in the heart.

Keywords: Apoptosis; Heart; Ischemia; NAD+; Reperfusion; Sirt1.

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References

    1. Virag L, Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev. 2002;54:375–429. - PubMed
    1. Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 2000;403:795–800. - PubMed
    1. Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev. 2000;14:1021–1026. - PubMed
    1. Ha CW, Huh WK. The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae. Aging (Albany NY) 2011;3:319–324. - PMC - PubMed
    1. Revollo JR, Grimm AA, Imai S. The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals. Curr Opin Gastroenterol. 2007;23:164–170. - PubMed

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