Promising cell-based immunotherapy using gamma delta T cells: together is better
- PMID: 25278452
- DOI: 10.1158/1078-0432.CCR-14-1371
Promising cell-based immunotherapy using gamma delta T cells: together is better
Abstract
Gamma delta T-cell response to cellular stress signals expressed by tumor cells makes them promising candidates for cancer immunotherapy. The proof of concept for clinical scale propagation of polyclonal γδ T-cell lines with efficient in vitro and in vivo response against cancer is an important step in this direction.
©2014 American Association for Cancer Research.
Comment on
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Activating and propagating polyclonal gamma delta T cells with broad specificity for malignancies.Clin Cancer Res. 2014 Nov 15;20(22):5708-19. doi: 10.1158/1078-0432.CCR-13-3451. Epub 2014 May 15. Clin Cancer Res. 2014. PMID: 24833662 Free PMC article.
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Neuroblastoma killing properties of Vδ2 and Vδ2-negative γδT cells following expansion by artificial antigen-presenting cells.Clin Cancer Res. 2014 Nov 15;20(22):5720-32. doi: 10.1158/1078-0432.CCR-13-3464. Epub 2014 Jun 3. Clin Cancer Res. 2014. PMID: 24893631 Free PMC article.
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