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. 2015 Sep;47(7):816-25.
doi: 10.1111/and.12336. Epub 2014 Oct 3.

Protective effect of beta-carotene against titanium dioxide nanoparticles induced apoptosis in mouse testicular tissue

M Orazizadeh  1   2 , E Daneshi  1 , M Hashemitmar  1   2 , F Absalan  1 , L Khorsandi  1   2
Affiliations

Protective effect of beta-carotene against titanium dioxide nanoparticles induced apoptosis in mouse testicular tissue

M Orazizadeh et al. Andrologia. 2015 Sep.

Abstract

In this study, the effects of beta-carotene (BC) on testicular germ cell apoptosis arising from titanium dioxide nanoparticles (NTiO2 ) have been evaluated. In NTiO2 -treated mice, expression of apoptotic related genes including Bid, FasL, caspase-3 and p38MAPK was significantly increased. Measurement apoptosis using TUNEL method showed significant increase in apoptotic index of germ cells in NTiO2 -treated mice (P < 0.05). TUNEL assessments showed that the increase of apoptotic index of testicular germ cells in NTiO2 -treated mice was reversed by BC. Beta-carotene pre-treatment could also effectively attenuate the expression of apoptotic related genes. The application of BC may serve as a beneficial medication to protect germ cells against apoptosis induced by nanoparticles and be helpful for male fertility.

Keywords: Apoptosis; nanomaterials; spermatogenesis.

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