Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Sep;44(5):355-7.
doi: 10.4070/kcj.2014.44.5.355. Epub 2014 Sep 25.

Prasugrel-induced hypersensitivity skin reaction

Soo-Han Kim  1 , Sang-Don Park  1 , Yong-Soo Baek  1 , Seon-Young Lee  1 , Sung-Hee Shin  1 , Sung-Il Woo  1 , Dae-Hyeok Kim  1 , Jun Kwan  1
Affiliations

Prasugrel-induced hypersensitivity skin reaction

Soo-Han Kim et al. Korean Circ J. 2014 Sep.

Abstract

We report a case of hypersensitivity skin reaction to prasugrel. The patient exhibited a generalized skin rash after treatment with prasugrel, which was resolved after discontinuation of prasugrel and substitution to clopidogrel. Clopidogrel was successfully administered as an alternative to prasugrel without any signs of further hypersensitivity.

Keywords: Clopidogrel; Exanthema; Hypersensitivity; Prasugrel; Thienopyridine.

PubMed Disclaimer

Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Fig. 1
Fig. 1
Photographs of patient with prasugrel-induced hypersensitivity skin reaction. A: exanthema on both forearms and hands. (A) shows exanthema on both forearms and hands after 5 days of prasugrel exposure. B: exanthema on the anterior chest and abdominal wall. (B) shows exanthema on anterior chest and abdominal wall.
Fig. 2
Fig. 2
Microscopic section of punch biopsy of abdominal wall. Microscopic sections demonstrating perivascular lymphocyte infiltration of dermis and epidermis compatible with a hypersensitivity skin reaction.
See this image and copyright information in PMC

References

    1. Wiviott SD, Braunwald E, McCabe C, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007;357:2001–2015. - PubMed
    1. Deshmukh AJ, Pant S, Cook J, Sachdeva R, Rutlen D, Uretsky BF. Prasugrel-induced rash. Ann Pharmacother. 2012;46:1123–1125. - PubMed
    1. Lokhandwala J, Best PJ, Henry Y, Berger PB. Allergic reactions to clopidogrel and cross-reactivity to other agents. Curr Allergy Asthma Rep. 2011;11:52–57. - PubMed
    1. Lokhandwala JO, Best PJ, Butterfield JH, et al. Frequency of allergic or hematologic adverse reactions to ticlopidine among patients with allergic or hematologic adverse reactions to clopidogrel. Circ Cardiovasc Interv. 2009;2:348–351. - PubMed
    1. Mehta SR, Yusuf S, Peters RJ, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358:527–533. - PubMed

LinkOut - more resources