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. 2014 Sep 28;72(1):32.
doi: 10.1186/2049-3258-72-32. eCollection 2014.

Effects of vitamin D in the elderly population: current status and perspectives

Olivier Bruyère  1 , Etienne Cavalier  2 , Jean-Claude Souberbielle  3 , Heike A Bischoff-Ferrari  4 , Charlotte Beaudart  1 , Fanny Buckinx  1 , Jean-Yves Reginster  1 , René Rizzoli  5
Affiliations

Effects of vitamin D in the elderly population: current status and perspectives

Olivier Bruyère et al. Arch Public Health. .

Abstract

Besides its well-known effect on bone metabolism, recent researches suggest that vitamin D may also play a role in the muscular, immune, endocrine, and central nervous systems. Double-blind RCTs support vitamin D supplementation at a dose of 800 IU per day for the prevention of falls and fractures in the senior population. Ecological, case-control and cohort studies have suggested that high vitamin D levels were associated with a reduced risk of autoimmune diseases, type 2 diabetes, cardio-vascular diseases and cancer but large clinical trials are lacking today to provide solid evidence of a vitamin D benefit beyond bone health. At last, the optimal dose, route of administration, dosing interval and duration of vitamin D supplementation at a specific target dose beyond the prevention of vitamin D deficiency need to be further investigated.

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