Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Nov;2(6):960-962.
doi: 10.3892/mco.2014.366. Epub 2014 Jul 31.

Bladder extragastrointestinal stromal tumor in an adolescent patient: A case-based review

Fan He  1 , Zhenqiang Fang  1 , Pei Zhu  1 , Wei Huang  1 , Longkun Li  1
Affiliations

Bladder extragastrointestinal stromal tumor in an adolescent patient: A case-based review

Fan He et al. Mol Clin Oncol. 2014 Nov.

Abstract

Extragastrointestinal stromal tumors (EGISTs) are mesenchymal tumors occurring outside the gastrointestinal tract, with histological, immunohistochemical and molecular genetic characteristics similar to those of gastrointestinal stromal tumors (GISTs). The immunohistochemical examination usually demonstrates a positive expression for CD117. GISTs are rare neoplasms and EGISTs are even less common. This is the report of a case of EGIST in the urinary bladder of a 15-year-old adolescent female patient who presented with painless gross hematuria. Pelvic computed tomography revealed an irregular soft tissue density mass, sized 5.7×4.8 cm, in the bladder. Partial cystectomy was performed in April, 2011. There was no recurrence during follow-up over the next 35 months, as determined by transabdoninal ultrasonography and cystoscopic examination. The patient in this study did not receive any molecular-targeted drugs. To the best of our knowledge, this is the first reported case of an EGIST of the urinary bladder in an adolescent patient.

Keywords: CD117; adolescent; bladder; extragastrointestinal stromal tumor.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Computed tomography indicated an irregular soft tissue density mass, sized 5.7×4.8 cm, in the urinary bladder.
Figure 2
Figure 2
Hematoxylin and eosin-stained section of the tumor. (A) The tumor was composed of fusiform cells with abundant acidophilic cytoplasm and clavate nuclei, round at both ends and mostly blunt. (B) The cells were mostly arranged in interwoven bundles or swirls and were mildly atypical.
Figure 3
Figure 3
Tumor cells positively stained for CD117.
See this image and copyright information in PMC

References

    1. Llenas-Garcia J, Guerra-Vales JM, Moreno A, Ibarrola C, Castelbon FJ, Fernandez-Ruiz M, Meneu JC, Ballestin C, Moreno E. Primary extragastrointestinal stromal tumors in the omentum and mesentery: a clinicopathological and immunohistochemical study. Hepatogastroenterology. 2008;55:1002–1005. - PubMed
    1. Miettinen M, Monihan JM, Sarlomo-Rikala M, Kovatich AJ, Carr NJ, Emory TS, Sobin LH. Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 1999;23:1109–1118. - PubMed
    1. Reith JD, Goldblum JR, Lyles RH, Weiss SW. Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol. 2000;13:577–585. - PubMed
    1. Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol. 2002;33:459–465. - PubMed
    1. Lasota J, Carlson JA, Miettinen M. Spindle cell tumor of urinary bladder serosa with phenotypic and genotypic features of gastrointestinal stromal tumor. Arch Pathol Lab Med. 2000;124:894–897. - PubMed

LinkOut - more resources