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Comment
. 2014 Nov;24(11):1189-90.
doi: 10.1111/pan.12525.

The addition of tramadol to a standard i.v. acetaminophen/morphine analgesia protocol in neonates: purposeful or just polypharmacy?

Karel Allegaert  1 , John N van den Anker
Affiliations
Comment

The addition of tramadol to a standard i.v. acetaminophen/morphine analgesia protocol in neonates: purposeful or just polypharmacy?

Karel Allegaert et al. Paediatr Anaesth. 2014 Nov.
No abstract available

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Conflict of interest statement

Conflict of interest:

IRB approval:No

Comment on

References

    1. Olishar M, Palmer GM, Orsini F, et al. The addition of tramadol to the standard of IV acetaminophen and morphine infusion for postoperative analgesia in neonates offers no clinical benefit: a randomized placebo-controlled trial. Paediatr Anaesth. 2014 - PubMed
    1. Allegaert K, Tibboel D, van den Anker J. Pharmacological treatment of neonatal pain: in search of a new equipoise. Semin Fetal Neonatal Med. 2013;18:42–47. - PMC - PubMed
    1. Krekels EH, Tibboel D, de Wildt SN, et al. Evidence-based morphine dosing for postoperative neonates and infants. Clin Pharmacokinet. 2014;53:553–563. - PubMed
    1. Ceelie I, de Wildt SN, van Dijk M, et al. Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial. JAMA. 2013;309:149–154. - PubMed
    1. Berde CB, Walco GA, Krane EJ, et al. Pediatric analgesic clinical trial designs, measures, and extrapolation: report of an FDA scientific workshop. Pediatrics. 2012;129:354–364. - PMC - PubMed

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