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Comment
. 2014 Oct 2;15(4):399-400.
doi: 10.1016/j.stem.2014.09.012.

When old hematopoietic stem cells get damaged

Jean Soulier  1
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Free article
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When old hematopoietic stem cells get damaged

Jean Soulier. Cell Stem Cell. .
Free article

Abstract

Hematopoietic stem cells (HSCs) functionally decline and are prone to lineage bias and myeloid malignancies upon aging. Two recent studies (Beerman et al., 2014; Flach et al., 2014) investigate the underlying mechanisms associated with aged HSC phenotypes and highlight DNA damage, replication stress, and ribosomal stress in the process.

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