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Comment
. 2014 Oct 2;15(4):401-402.
doi: 10.1016/j.stem.2014.09.010.

Inflamm-aging: STAT3 signaling pushes muscle stem cells off balance

Bénédicte Chazaud  1 , Guy Mouchiroud  2
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Inflamm-aging: STAT3 signaling pushes muscle stem cells off balance

Bénédicte Chazaud et al. Cell Stem Cell. .
Free article

Abstract

Two recent studies shed light on mechanisms underlying muscle dysfunction in age and disease. They reveal that JAK-STAT signaling regulates myogenic differentiation, leading to a reduced reservoir of muscle stem cells. Both genetic and pharmacologic inhibition of STAT3 signaling improve stem cell homeostasis and physiology of aged and dystrophic muscles.

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