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Review
. 2014 Oct:21:45-50.
doi: 10.1016/j.mib.2014.09.002. Epub 2014 Sep 30.

The antibiotic resistome: what's new?

Julie Ann Perry  1 , Erin Louise Westman  1 , Gerard D Wright  2
Affiliations
Review

The antibiotic resistome: what's new?

Julie Ann Perry et al. Curr Opin Microbiol. 2014 Oct.

Abstract

The antibiotic resistome is dynamic and ever expanding, yet its foundations were laid long before the introduction of antibiotics into clinical practice. Here, we revisit our theoretical framework for the resistome concept and consider the many factors that influence the evolution of novel resistance genes, the spread of mobile resistance elements, and the ramifications of these processes for clinical practice. Observing the trends and prevalence of genes within the antibiotic resistome is key to maintaining the efficacy of antibiotics in the clinic.

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