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Observational Study
. 2014 Nov 4;83(19):1705-11.
doi: 10.1212/WNL.0000000000000958. Epub 2014 Oct 3.

Elevated rates of intracerebral hemorrhage in individuals from a US clinical care HIV cohort

Felicia C Chow  1 , Wei He  2 , Peter Bacchetti  2 , Susan Regan  2 , Steven K Feske  2 , James B Meigs  2 , Steven K Grinspoon  2 , Virginia A Triant  2
Affiliations
Observational Study

Elevated rates of intracerebral hemorrhage in individuals from a US clinical care HIV cohort

Felicia C Chow et al. Neurology. .

Abstract

Objective: To compare rates of intracerebral hemorrhage (ICH) in HIV-infected and uninfected individuals in a large clinical care cohort and to assess risk factors associated with ICH.

Methods: We identified incident ICH in HIV-infected and uninfected control cohorts from the Partners Health Care system using ICD-9-CM codes. We constructed Cox proportional hazards models to estimate adjusted hazard ratios for HIV infection and other predictors of ICH.

Results: The incidence rate of ICH was 2.29 per 1,000 person-years in HIV-infected individuals compared with 1.23 per 1,000 person-years in uninfected individuals, with an unadjusted incidence rate ratio of 1.85 (95% confidence interval 1.37-2.47, p < 0.001). In a multivariable model, HIV infection was independently associated with a higher hazard of ICH, although its effect diminished with increasing age. Female sex was associated with a lower hazard of ICH in the uninfected cohort but not in the HIV cohort. CD4 count <200 × 10(6) cells/L and anticoagulant use were predictive of ICH.

Conclusions: HIV infection conferred an increased adjusted hazard of ICH, which was more pronounced in young patients and in women.

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References

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