Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Oct;22(10):547-9.
doi: 10.1016/j.tim.2014.08.003.

Framing expectations in early HIV cure research

Karine Dubé  1 , Gail E Henderson  2 , David M Margolis  3
Affiliations

Framing expectations in early HIV cure research

Karine Dubé et al. Trends Microbiol. 2014 Oct.

Abstract

Language used to describe clinical research represents a powerful opportunity to educate volunteers. In the case of HIV cure research there is an emerging need to manage expectations by using the term 'experiment'. Cure experiments are proof-of-concept studies designed to evaluate novel paradigms to reduce persistent HIV-1 reservoirs, without any expectation of medical benefit.

Keywords: HIV cure research; expectations; experiments; trials.

PubMed Disclaimer

References

    1. Horwitz JP, et al. Nucleosides. V. The monomesylates of 1-(2′-deoxy-beta-Dlyxofuranosyl)thymidine. J. Org. Chem. 1964;29:2076–2078.
    1. Advisory Committee on Human Radiation Experiments. Final Report. US Government Printing Office; 1995.
    1. Prins JM, et al. Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1 infected patients on potent antiretroviral therapy. AIDS. 1999;13:2405–2410. - PubMed
    1. Gordin F, et al. CD4+ count-guided interruption of antiretroviral treatment. N. Engl. J. Med. 2006;355:2283–2296. - PubMed
    1. Allers K, et al. Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation. Blood. 2011;117:2791–2799. - PubMed

Publication types