Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Dec;38(8):503-7.
doi: 10.1053/j.semperi.2014.08.015. Epub 2014 Oct 1.

Oseltamivir for influenza in pregnancy

Richard H Beigi  1 , Raman Venkataramanan  2 , Steve N Caritis  3
Affiliations
Review

Oseltamivir for influenza in pregnancy

Richard H Beigi et al. Semin Perinatol. 2014 Dec.

Abstract

Pregnancy predisposes women to disproportionate morbidity and mortality from influenza infections. This is true for both seasonal epidemics as well as occasional pandemics. Inactivated yearly influenza vaccines are the best available method of disease prevention and are recommended for all pregnant women in any trimester of pregnancy and postpartum. Oseltamivir (Tamiflu(®)) is currently the first-line recommended and most commonly used pharmaceutical agent for influenza prophylaxis and treatment. Oseltamivir has been demonstrated to prevent disease among exposed individuals, as well as to shorten the duration of illness and lessen the likelihood of complications among those infected. The physiologic adaptations of pregnancy may alter the pharmacokinetics and pharmacodynamics of this important drug. Updated evidence regarding these potential alterations, current knowledge gaps, and future investigative directions is discussed.

Keywords: Influenza; Oseltamivir; Pharmacology; Pregnancy.

PubMed Disclaimer

Figures

Fig
Fig
Structure of Oseltamivir parent drug (OP) and active metabolite (OC).
See this image and copyright information in PMC

References

    1. CDC. Prevention and control of influenza with vaccines. Recommendations of the advisory committee on immunization practices (ACIP), 2010. MMWR Morb Mortal Wkly Rep. 2010;59(RR-8):1–62. - PubMed
    1. Irving WL, James DK, Stephenson T, et al. Influenza virus infection in the second and third trimesters of pregnancy: a clinical and seroepidemiological study. BJOG. 2000;107:1282–1289. - PubMed
    1. Neuzil KM, Reed GW, Mitchel EF, Simonsen L, Griffin MR. Impact of influenza on acute cardiopulmonary hospitalizations in pregnant women. Am J Epidemiol. 1998;148:1094–1102. - PubMed
    1. Beigi RH. Clin Obstet Gynecol. 2012;55(4):914–926. - PubMed
    1. Jamieson DJ, Honein MA, Rasmussen SA, et al. H1N1 2009 influenza virus infection during pregnancy in the USA. Lancet. 2009;374(9688):451–458. - PubMed

Publication types