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Review
. 2014 Dec;30(3):579-89.
doi: 10.1016/j.cveq.2014.08.004. Epub 2014 Sep 30.

Hendra virus

Deborah Middleton  1
Affiliations
Review

Hendra virus

Deborah Middleton. Vet Clin North Am Equine Pract. 2014 Dec.

Abstract

Hendra virus infection of horses occurred sporadically between 1994 and 2010 as a result of spill-over from the viral reservoir in Australian mainland flying-foxes, and occasional onward transmission to people also followed from exposure to affected horses. An unprecedented number of outbreaks were recorded in 2011 leading to heightened community concern. Release of an inactivated subunit vaccine for horses against Hendra virus represents the first commercially available product that is focused on mitigating the impact of a Biosafety Level 4 pathogen. Through preventing the development of acute Hendra virus disease in horses, vaccine use is also expected to reduce the risk of transmission of infection to people.

Keywords: Disease; Emerging; Hendra; Horse; Infectious; Pathogenesis; Vaccine; Zoonotic.

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Conflict of interest statement

Conflict of interest:

Dr Middleton: Nil

Figures

Figure 1
Figure 1
Figure 1A: Locations of HeV events between 1994 and 2010, highlighting the distribution of Pt. alecto and the low lying coastal regions on the 9 sec digital elevation model. Figure 1B: Locations of HeV events between 2011 and 2013, highlighting the distribution of Pteropus alecto, the low lying coastal regions on the 9 sec digital elevation model and Chinchilla, the first case west of the Great Dividing Range
Figure 1
Figure 1
Figure 1A: Locations of HeV events between 1994 and 2010, highlighting the distribution of Pt. alecto and the low lying coastal regions on the 9 sec digital elevation model. Figure 1B: Locations of HeV events between 2011 and 2013, highlighting the distribution of Pteropus alecto, the low lying coastal regions on the 9 sec digital elevation model and Chinchilla, the first case west of the Great Dividing Range
Figure 2
Figure 2
Figure 2A: Histological section of lymph node from horse with acute HeV infection showing lymphadenitis with syncytial cell formation. HE Figure 2B: HeV antigen in section adjacent to Fig 2A. Anti-Nipah N antibody.
Figure 2
Figure 2
Figure 2A: Histological section of lymph node from horse with acute HeV infection showing lymphadenitis with syncytial cell formation. HE Figure 2B: HeV antigen in section adjacent to Fig 2A. Anti-Nipah N antibody.
See this image and copyright information in PMC

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