Arginine metabolism in asthma

Abstract

Nitric oxide (NO) is important in the regulation of airway tone and airway responsiveness. Alterations in the L-arginine metabolism resulting in reduced availability of the substrate L-arginine for NO synthases, as well as the presence of NO synthase inhibitors such as asymmetric dimethylarginine, contribute to the reduced NO formation and airway dysfunction in asthma. Therapeutic interventions aiming to modulate the impaired L-arginine metabolism may help correct the enhanced airway tone and responsiveness in asthma.

Keywords: ADMA; Agmatine; Arginase; Arginine metabolism; Citrulline; Nitric oxide synthase; Ornithine; Polyamine.