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Observational Study
. 2014 Oct;89(10):1360-7.
doi: 10.1016/j.mayocp.2014.07.004.

Prospective cohort study of the effectiveness of smoking cessation treatments used in the "real world"

Daniel Kotz  1 , Jamie Brown  2 , Robert West  2
Affiliations
Observational Study

Prospective cohort study of the effectiveness of smoking cessation treatments used in the "real world"

Daniel Kotz et al. Mayo Clin Proc. 2014 Oct.

Abstract

Objective: To estimate the "real-world" effectiveness of commonly used aids to smoking cessation in England by using longitudinal data.

Patients and methods: We conducted a prospective cohort study in 1560 adult smokers who participated in an English national household survey in the period from November 2006 to March 2012, responded to a 6-month follow-up survey, and made at least 1 quit attempt between the 2 measurements. The quitting method was classified as follows: (1) prescription medication (nicotine replacement therapy [NRT], bupropion, or varenicline) in combination with specialist behavioral support delivered by a National Health Service Stop Smoking Service; (2) prescription medication with brief advice; (3) NRT bought over the counter; (4) none of these. The primary outcome measure was self-reported abstinence up to the time of the 6-month follow-up survey, adjusted for key potential confounders including cigarette dependence.

Results: Compared with smokers using none of the cessation aids, the adjusted odds of remaining abstinent up to the time of the 6-month follow-up survey were 2.58 (95% CI, 1.48-4.52) times higher in users of prescription medication in combination with specialist behavioral support and 1.55 (95% CI, 1.11-2.16) times higher in users of prescription medication with brief advice. The use of NRT bought over the counter was associated with a lower odds of abstinence (odds ratio, 0.68; 95% CI, 0.49-0.94).

Conclusion: Prescription medication offered with specialist behavioral support and that offered with minimal behavioral support are successful methods of stopping cigarette smoking in England.

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References

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