Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2015 Feb;61(2):428-30.
doi: 10.1002/hep.27550. Epub 2015 Jan 5.

Hepatic congestion leads to fibrosis: findings in a newly developed murine model

Hisashi Hidaka  1 , Yasuko Iwakiri
Affiliations
Editorial

Hepatic congestion leads to fibrosis: findings in a newly developed murine model

Hisashi Hidaka et al. Hepatology. 2015 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: We have no financial interest in or financial conflicts with the subject matter or materials discussed in this manuscript.

Figures

Figure 1
Figure 1. Sinusoidal thrombosis and mechanical strain lead to liver fibrosis in congestive hepatopathy
In the coagulation process, mature fibrin clots are formed through cleavage of circulating fibrinogen by the action of thrombin, a potent plasma protease. Fibrin formation promotes binding of fibronectin (FN) to fibril (FN fibril assembly), a key process of the development of a provisional extracellular matrix (ECM). FN fibril assembly is initiated by binding of FN to integrins, mainly α5β1 integrin, which is assembled with intracellular contractile filammantous actin in hepatic stellate cells (HSCs). The assembly of filammantous actin is regulated by bidirectional signaling between Rho kinase activity and integrins. Similarly, mechanical strain due to hepatic congestion promotes FN fibril assembly in the integrin and actin dependent manner.
See this image and copyright information in PMC

Comment on

References

    1. Giallourakis CC, Rosenberg PM, Friedman LS. The liver in heart failure. Clin Liver Dis. 2002;6:947–967. - PubMed
    1. Bayraktar UD, Seren S, Bayraktar Y. Hepatic venous outflow obstruction: three similar syndromes. World J Gastroenterol. 2007;13:1912–1927. - PMC - PubMed
    1. Simonetto DA, Yang HY, Yin M, deAssuncao TM, Kwon JH, Hilsher M, et al. Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces. Hepatology. 2014 - PMC - PubMed
    1. Kendall TJ, Stedman B, Hacking N, Haw M, Vettukattill JJ, Salmon AP, et al. Hepatic fibrosis and cirrhosis in the Fontan circulation: a detailed morphological study. J Clin Pathol. 2008;61:504–508. - PubMed
    1. Lwaleed BA, Bass PS. Tissue factor pathway inhibitor: structure, biology and involvement in disease. J Pathol. 2006;208:327–339. - PubMed