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. 2014 Sep;18(5):721-5.
doi: 10.4103/2230-8210.139241.

Vitamin D status and risk of ischemic stroke in North Indian patients

Anu Gupta  1 , Sudesh Prabhakar  1 , Manish Modi  1 , Sanjay Kumar Bhadada  2 , Vivek Lal  1 , Dheeraj Khurana  1
Affiliations

Vitamin D status and risk of ischemic stroke in North Indian patients

Anu Gupta et al. Indian J Endocrinol Metab. 2014 Sep.

Abstract

Context: Accumulating evidence suggests that vitamin D deficiency is associated with increased risk of stroke. Contributing mechanisms have been linked to the association of vitamin D deficiency with the presence of hypertension, diabetes mellitus, and atherosclerosis, however, the evidence is conflicting.

Aims: This study sought to determine the association of vitamin D deficiency with ischemic stroke and its risk factors.

Settings and design: Cross-sectional case control study.

Subjects and methods: We measured serum 25-hydroxyvitamin D [25(OH) D] and intact parathyroid hormone (iPTH) levels in 73 patients of ischemic stroke, presenting within 7 days of onset of stroke and compared with 70 age and gender matched controls.

Statistical analysis used: The statistical analysis was carried out using Statistical Package for Social Sciences (SPSS Inc., Chicago, IL, version 17.0 for Windows).

Results: The mean age of patients and controls was 59.9 ± 11.2 years and 57.9 ± 9.7 years, respectively (P = 0.26). Of 67.1% patients were men as compared to 65.7% controls (P = 0.86). There was no significant difference in the prevalence of vitamin D deficiency/insufficiency (P = 0.25), mean 25(OH) D levels (P = 0.75), and iPTH levels (P = 0.10) between cases and controls. No association of vitamin D deficiency/insufficiency was found with the prevalent risk factors in cases of ischemic stroke.

Conclusions: Vitamin D deficiency does not bear an association with ischemic stroke or its risk factors.

Keywords: Asian; Indian; Vitamin D; ischemic; risk; stroke.

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Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Pilz S, Tomaschitz A, Drechsler C, Zittermann A, Dekker JM, März W. Vitamin D supplementation: A promising approach for the prevention and treatment of strokes. Curr Drug Targets. 2011;12:88–96. - PubMed
    1. Brøndum-Jacobsen P, Nordestgaard BG, Schnohr P, Benn M. 25-Hydroxyvitamin D and symptomatic ischemic stroke: An original study and meta-analysis. Ann Neurol. 2013;73:38–47. - PubMed
    1. Kojima G, Bell C, Abbott RD, Launer L, Chen R, Motonaga H, et al. Low dietary vitamin D predicts 34-year incident stroke: The Honolulu Heart Program. Stroke. 2012;43:2163–7. - PMC - PubMed
    1. Sun Q, Pan A, Hu FB, Manson JE, Rexrode KM. 25-Hydroxyvitamin D levels and the risk of stroke: A prospective study and meta-analysis. Stroke. 2012;43:1470–7. - PMC - PubMed
    1. Drechsler C, Pilz S, Obermayer-Pietsch B, Verduijn M, Tomaschitz A, Krane V, et al. Vitamin D deficiency is associated with sudden cardiac death, combined cardiovascular events, and mortality in haemodialysis patients. Eur Heart J. 2010;31:2253–61. - PMC - PubMed