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. 2014 Sep 27:(91):51677.
doi: 10.3791/51677.

A preclinical murine model of hepatic metastases

Kevin C Soares  1 , Kelly Foley  2 , Kelly Olino  1 , Ashley Leubner  2 , Skye C Mayo  1 , Ajay Jain  1 , Elizabeth Jaffee  2 , Richard D Schulick  3 , Kiyoshi Yoshimura  4 , Barish Edil  5 , Lei Zheng  6
Affiliations

A preclinical murine model of hepatic metastases

Kevin C Soares et al. J Vis Exp. .

Abstract

Numerous murine models have been developed to study human cancers and advance the understanding of cancer treatment and development. Here, a preclinical, murine pancreatic tumor model of hepatic metastases via a hemispleen injection of syngeneic murine pancreatic tumor cells is described. This model mimics many of the clinical conditions in patients with metastatic disease to the liver. Mice consistently develop metastases in the liver allowing for investigation of the metastatic process, experimental therapy testing, and tumor immunology research.

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