Are Hemoglobin-Based Oxygen Carriers Being Withheld Because of Regulatory Requirement for Equivalence to Packed Red Blood Cells?

Affiliations

¹ 1University of Maryland School of Medicine, Baltimore, MD; 2OPK Biotech LLC, Cambridge, MA; 3Inkosi Albert Luthuli Central Hospital and Nelson R. Mandela School of Medicine, Department of Anesthesia and Pain Management, Durban, South Africa; 4Milpark Clinic, Department of Surgery, Johannesburg, South Africa; 5Sunninghill Hospital, Department of Surgery, Johannesburg, South Africa; 6David Geffen School of Medicine, Department of Anesthsiology, University of California, Los Angeles, Los Angeles, CA; and 7Brown University School of Medicine, Department of Surgery, Providence, RI.

Comment

Colin F Mackenzie et al. Am J Ther. 2015 Jul-Aug.

. 2015 Jul-Aug;22(4):e115-21.

doi: 10.1097/MJT.0000000000000009.

¹ 1University of Maryland School of Medicine, Baltimore, MD; 2OPK Biotech LLC, Cambridge, MA; 3Inkosi Albert Luthuli Central Hospital and Nelson R. Mandela School of Medicine, Department of Anesthesia and Pain Management, Durban, South Africa; 4Milpark Clinic, Department of Surgery, Johannesburg, South Africa; 5Sunninghill Hospital, Department of Surgery, Johannesburg, South Africa; 6David Geffen School of Medicine, Department of Anesthsiology, University of California, Los Angeles, Los Angeles, CA; and 7Brown University School of Medicine, Department of Surgery, Providence, RI.

No abstract available

Comment on

Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis.
Natanson C, Kern SJ, Lurie P, Banks SM, Wolfe SM. Natanson C, et al. JAMA. 2008 May 21;299(19):2304-12. doi: 10.1001/jama.299.19.jrv80007. Epub 2008 Apr 28. JAMA. 2008. PMID: 18443023 Free PMC article.