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. 2014 Oct 17;16(20):5366-9.
doi: 10.1021/ol502572g. Epub 2014 Oct 6.

Curvulamine, a new antibacterial alkaloid incorporating two undescribed units from a Curvularia species

Wen Bo Han  1 , Yan Hua Lu, Ai Hua Zhang, Gao Fei Zhang, Ya Ning Mei, Nan Jiang, Xinxiang Lei, Yong Chun Song, Seik Weng Ng, Ren Xiang Tan
Affiliations

Curvulamine, a new antibacterial alkaloid incorporating two undescribed units from a Curvularia species

Wen Bo Han et al. Org Lett. .

Abstract

The white croaker (Argyrosomus argentatus) derived Curvularia sp. IFB-Z10 produces curvulamine as a skeletally unprecedented alkaloid incorporating two undescribed extender units. Curvulamine is more selectively antibacterial than tinidazole and biosynthetically unique in the new extenders formed through a decarboxylative condensation between an oligoketide motif and alanine.

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