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. 1989 Sep 14;341(6238):125-30.
doi: 10.1038/341125a0.

Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis

J Ostermann  1 , A L Horwich, W Neupert, F U Hartl
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Free article

Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis

J Ostermann et al. Nature. .
Free article

Abstract

Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochondria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding.

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  • The first chaperonin.
    Hartl FU, Hayer-Hartl M. Hartl FU, et al. Nat Rev Mol Cell Biol. 2013 Oct;14(10):611. doi: 10.1038/nrm3665. Nat Rev Mol Cell Biol. 2013. PMID: 24061226 No abstract available.

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