Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Nov;24(11):615-6.
doi: 10.1016/j.tcb.2014.09.005. Epub 2014 Oct 3.

Brd4 is on the move during inflammation

Yali Xu  1 , Christopher R Vakoc  2
Affiliations
Comment

Brd4 is on the move during inflammation

Yali Xu et al. Trends Cell Biol. 2014 Nov.

Abstract

Enhancer landscapes are shaped by the integrated functions of lineage-specific and signal-dependent transcription factors. A new study by Brown et al. suggests that the signal-dependent transcription factor NF-kB can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome. This work reveals new principles of enhancer dynamics and insights into the therapeutic modulation of enhancer function with BET bromodomain inhibitors.

Keywords: BET bromodomain; Brd4; JQ1; NF-kB; enhancer; inflammation; p65; super-enhancer.

PubMed Disclaimer

Comment on

References

    1. Spitz F, Furlong EEM. Transcription factors: from enhancer binding to developmental control. Nat Rev Genet. 2012;13:613–626. - PubMed
    1. Heinz S, et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Molecular Cell. 2010;38:576–589. - PMC - PubMed
    1. Jin F, et al. A high-resolution map of the three-dimensional chromatin interactome in human cells. Nature. 2013;503:290–294. - PMC - PubMed
    1. Kaikkonen Minna U, et al. Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription. Molecular Cell. 2013;51:310–325. - PMC - PubMed
    1. Ostuni R, et al. Latent enhancers activated by stimulation in differentiated cells. Cell. 2013;152:157–171. - PubMed

Publication types

MeSH terms