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. 1987;8(10):293-6.
doi: 10.1016/0167-5699(87)90014-4.

The T-cell antigen receptor gamma gene: rearrangement and cell lineages

J P Allison  1 , L L Lanier  2
Affiliations

The T-cell antigen receptor gamma gene: rearrangement and cell lineages

J P Allison et al. Immunol Today. 1987.

Abstract

Most adult T cells have a T-cell antigen receptor composed of αß heterodimers in a complex with the CD3 antigen. Immature thymocytes, however, can express CD3-associated heterodimers of a γ chain and another poorly characterized chain ('δ'). Here James Allison and Lewis Lanier suggest that thymocytes can develop along two mutually exclusive ontological pathways, giving rise to T cells that express either αß or γδ heterodimers, but not both or any other heterodimeric combination.

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