doi: 10.1016/0167-5699(83)90120-2.
The role of purine metabolic enzymes and terminal deoxynucleotidyl transferase in intrathymic T-cell differentiation
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- PMID: 25291281
- DOI: 10.1016/0167-5699(83)90120-2
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The role of purine metabolic enzymes and terminal deoxynucleotidyl transferase in intrathymic T-cell differentiation
Immunol Today.
1983 Mar.
Abstract
Most cortical thymocytes die within the thymus. It is proposed here that lethally high intracellular levels of deoxynucleosides are the cause of death. Developing thymocytes appropriately equipped for self-recognition are protected because contact with stromal cells prevents the lethal accumulation of deoxynucleosides.
Copyright © 1983. Published by Elsevier B.V.
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