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. 1983 Mar;4(3):65-8.
doi: 10.1016/0167-5699(83)90120-2.

The role of purine metabolic enzymes and terminal deoxynucleotidyl transferase in intrathymic T-cell differentiation

D D Ma  1 , T Sylwestrowicz, G Janossy, A V Hoffbrand
Affiliations

The role of purine metabolic enzymes and terminal deoxynucleotidyl transferase in intrathymic T-cell differentiation

D D Ma et al. Immunol Today. 1983 Mar.

Abstract

Most cortical thymocytes die within the thymus. It is proposed here that lethally high intracellular levels of deoxynucleosides are the cause of death. Developing thymocytes appropriately equipped for self-recognition are protected because contact with stromal cells prevents the lethal accumulation of deoxynucleosides.

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