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. 1985 Mar;6(3):72-4.
doi: 10.1016/0167-5699(85)90018-0.

Does T-cell restriction to Ia limit the need for self-tolerance?

C Cowing  1
Affiliations

Does T-cell restriction to Ia limit the need for self-tolerance?

C Cowing. Immunol Today. 1985 Mar.

Abstract

Why did two classes ofMHC molecule evolve as restricting elements in T-cell function? Here Carol Cowing discusses the hypothesis that incomplete self-tolerance may explain the necessity for class II MHC restriction.

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