[Treatment of tubal pregnancy with methotrexate]

Abstract

Three women with unruptured tubal pregnancy, confirmed by laparoscopy were treated with a total dose of 140 mg methotrexate. The medicament was given in two therapeutic cycles. The action of methotrexate in the trophoblastic tissue was evaluated by serial determinations of beta hCG. No side effects were observed during the treatment. When the level of beta hCG dropped to 10 mIU/ml, the entire ectopic foetus (including the amnion, membrane, trophoderm and all pertaining tissue and fluids) was removed through the tube by massage after minilaparotomy. The patency of tubes proved to be normal on performing postoperative hysterosalpingography. One of the three patients delivered a healthy baby, another is in the third trimester of a normal pregnancy.