[Withdrawal versus continuation of antipsychotic drugs in people with dementia]

Abstract

Antipsychotics are often prescribed for treatment of psychiatric symptoms. The efficacy is very limited and must be weighed against the risk of adverse effects. A Cochrane review included randomized, placebo-controlled trials comparing an antipsychotic withdrawal with continuing treatment. Nine studies (606 patients) were included. Only in two studies with patients who had responded to antipsychotic treatment, withdrawal resulted in an increased risk of relapse. Withdrawal of antipsychotics should be incorporated in daily practice in primary care.