[Pharmacotherapy effectiveness for some symptoms of borderline personality disorder]

Abstract

A high percentage of patients with borderline personality disorder (BPD) are prescribed psychotropic medications. Recent meta-analyses of randomized controlled trials suggested evidence of effects of antiepileptics on impulsivity and anger and of atypical antipsychotics on cognitive-perceptual symptoms and anger. Antidepressants had no or negligible effect. Total BPD severity was not significantly reduced by pharmacotherapy. Longitudinal studies suggest that BPD tends to improve, but it is not clarified whether long-term pharmacotherapy make the naturalistic recovery occur more rapidly.