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. 2014 Nov;7(6):1003-13.
doi: 10.1161/CIRCHEARTFAILURE.114.001391. Epub 2014 Oct 7.

Clinical outcomes after continuous-flow left ventricular assist device: a systematic review

Colleen K McIlvennan  1 , Kate H Magid  2 , Amrut V Ambardekar  2 , Jocelyn S Thompson  2 , Daniel D Matlock  2 , Larry A Allen  2
Affiliations

Clinical outcomes after continuous-flow left ventricular assist device: a systematic review

Colleen K McIlvennan et al. Circ Heart Fail. 2014 Nov.

Abstract

Background: Conveying the complex trade-offs of continuous-flow left ventricular assist devices is challenging and made more difficult by absence of an evidence summary for the full range of possible outcomes. We aimed to summarize the current evidence on outcomes of continuous-flow left ventricular assist devices.

Methods and results: PubMed and Cochrane Library were searched from January 2007 to December 2013, supplemented with manual review. Three reviewers independently assessed each study for saliency on patient-centered outcomes. Data were summarized in tabular form. Overall study characteristics encouraged inclusion of all indications (destination therapy and bridge to transplant) and prevented meta-analysis. The electronic search identified 465 abstracts, of which 50 met inclusion criteria; manual review added 2 articles in press. The articles included 10 industry-funded trials and registries, 10 multicenter reports, and the remainder single-center observational experiences. Estimated actuarial survival after continuous-flow left ventricular assist devices ranged from 56% to 87% at 1 year, 43% to 84% at 2 years, and 47% at 4 years. Improvements in functional class and quality of life were reported, but missing data complicated interpretation. Adverse events were experienced by the majority of patients, but estimates for bleeding, stroke, infection, right heart failure, arrhythmias, and rehospitalizations varied greatly.

Conclusions: The totality of data for continuous-flow left ventricular assist devices show consistent improvements in survival and quality of life counterbalanced by a range of common complications. Although this summary should provide a practical resource for healthcare provider-led discussions with patients, it highlights the critical need for high-quality patient-centered data collected with standard definitions.

Keywords: heart failure; heart-assist devices.

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Figures

Figure 1
Figure 1
Search Flow Diagram
Figure 2
Figure 2
Simplified One-Year Outcomes Using Weighted Averages for Left Ventricular Assist Device (Combined Bridge-to-Transplant and Destination Therapy)
See this image and copyright information in PMC

References

    1. Allen LA, Stevenson LW, Grady KL, Goldstein NE, Matlock DD, Arnold RM, Cook NR, Felker GM, Francis GS, Hauptman PJ, Havranek EP, Krumholz HM, Mancini D, Riegel B, Spertus JA. Decision making in advanced heart failure: a scientific statement from the American Heart Association. Circulation. 2012;125:1928–1952. - PMC - PubMed
    1. Beauchamp TL, Childress JF. Principles of Biomedical Ethics. 6th edition. Oxford: Oxford University Press; 2008.
    1. Feldman D, Pamboukian SV, Teuteberg JJ, Birks E, Lietz K, Moore SA, Morgan JA, Arabia F, Bauman ME, Buchholz HW, Deng M, Dickstein ML, El-Banayosa A, Elliot T, Goldstein DJ, Grady KL, Jones K, Hryniewicz K, John R, Kaan A, Kusne S, Loebe M, Massicotte MP, Moazami N, Mohacsi P, Mooney M, Nelson T, Pagani F, Perry W, Potapov EV, Eduardo Rame J, Russell SD, Sorensen EN, Sun B, Strueber M, Mangi AA, Petty MG, Rogers J. The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: executive summary. J Heart Lung Transplant. 2013;32:157–187. - PubMed
    1. Peters E, Västfjäll D, Slovic P, Mertz CK, Mazzocco K, Dickert S. Numeracy and decision making. Psychological Science. 2006;17:408–414. - PubMed
    1. Matlock DD, Nowels CT, Masoudi FA, Sauer WH, Bekelman DB, Main DS, Kutner JS. Patient and cardiologist perceptions of decision making for implantable cardioverter-defibrillators: a qualitative study. Pacing Clin Electrophysiol. 2001;34:1634–1644. - PubMed

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