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. 2014 Nov;8(5):2325-2327.
doi: 10.3892/ol.2014.2493. Epub 2014 Sep 1.

Mixed adenocarcinoma, sarcomatoid carcinoma and adenosquamous carcinoma of the prostate: A case report

Zhongfu Zhang  1 , Yadong Wang  2 , Qing Zhao  2 , Ganhong Li  2 , Xingqi Zhao  2 , Jun Li  2 , Xianxin Li  3
Affiliations

Mixed adenocarcinoma, sarcomatoid carcinoma and adenosquamous carcinoma of the prostate: A case report

Zhongfu Zhang et al. Oncol Lett. 2014 Nov.

Abstract

Adenosquamous carcinoma (ASC) and sarcomatoid carcinoma (SC) of the prostate are rare, but highly aggressive tumors. The occurrence of mixed carcinomas in the prostate is even more rarely reported. The present study reports the case of a 62-year-old male who was diagnosed with prostatic adenocarcinoma accompanied by multiple bone metastases, as shown by a needle biopsy and skeletal computed tomography scan. The patient was treated with hormonal therapy, but thereafter, specimens from a transurethral resection of the prostate (TURP) were found to be composed of three histologically distinct elements: ASC, SC and adenocarcinoma. The level of p53 was evaluated by immunohistochemistry in detail, and it was found that this was significantly increased in the TURP samples compared with the needle biopsy samples. The abnormal level of p53 was likely associated with the prognosis of the patient; the patient succumbed to prostate carcinoma two months after the confirmation of the diagnosis.

Keywords: adenocarcinoma; adenosquamous carcinoma; p53; prostate carcinoma; sarcomatoid carcinoma.

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Figures

Figure 1
Figure 1
Computed tomography of the abdomen and pelvis. (A) The tumor infiltrated outside of the rectum. (B) The presence of hydronephrosis, retroperitoneal lymph node metastasis and seroperitoneum in the patient.
Figure 2
Figure 2
Hematoxylin and eosin and immunohistochemical staining of the prostatic specimen from the (A, E and F) needle biopsy and (B–D and G–I) transurethral resection of the prostate. (A) Prostatic adenocarcinoma. (B) Prostatic adenocarcinoma. (C) Squamous components; the centre of the image exhibits evidence of keratin pearl formation. (D) Sarcomatoid carcinoma (SC) sample exhibiting poorly-differentiated spindle cells with large hyperchromatic nuclei. (E) Gland area; negative for p53 expression. (F) Interstitial area; weakly positive for p53 expression. (G) Adenocarcinoma; positive for p53 expression. (H) Adenosquamous carcinoma; positive for p53 expression. (I) SC; positive for p53 expression. p53 expression is indicated by immunohistochemical staining for p53. (A, E and F) ×200 magnification; (B–D and G–I) ×400 magnification.
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