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Comment
. 2014 Oct 7;20(4):554-5.
doi: 10.1016/j.cmet.2014.09.009.

Break on through to the other 1

Alexei Kharitonenkov  1 , Richard DiMarchi  2
Affiliations
Free article
Comment

Break on through to the other 1

Alexei Kharitonenkov et al. Cell Metab. .
Free article

Abstract

Although discovered in 1974, FGF1 was previously unrealized to have a role in metabolism. Suh et al. (2014) now report impressive pharmacological outcomes of FGF1 therapy in mice that imply this protein is an important metabolic regulator with therapeutic potential in the treatment of insulin resistance and type 2 diabetes.

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Comment on

  • Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.
    Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. Suh JM, et al. Nature. 2014 Sep 18;513(7518):436-9. doi: 10.1038/nature13540. Epub 2014 Jul 16. Nature. 2014. PMID: 25043058 Free PMC article.