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. 1989;281(5):362-5.
doi: 10.1007/BF00412983.

Pharmacological studies on dithranol-induced irritative dermatitis in mice

L Kemény  1 , M Csató, A Dobozy
Affiliations

Pharmacological studies on dithranol-induced irritative dermatitis in mice

L Kemény et al. Arch Dermatol Res. 1989.

Abstract

The effects of different pharmacological substances on dithranol-induced irritative dermatitis were studied in mice. Pretreatment of the animals with a specific platelet activating factor (PAF) antagonist, BN 52021, significantly reduced the ear swelling in a dose-dependent manner. The cyclooxygenase inhibitor indomethacin, the antihistamine clemastine, and the anti-oxidant superoxide dismutase also proved to be effective in the reduction of the dermatitis. The results provide evidence of the coinvolvement of PAF, prostaglandins, histamine, and reactive oxygen radicals in dithranol-induced irritative dermatitis in mice.

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References

    1. Br J Dermatol. 1985 Mar;112(3):285-90 - PubMed
    1. J Allergy Clin Immunol. 1988 May;81(5 Pt 1):919-34 - PubMed
    1. Br Med Bull. 1983 Jul;39(3):277-80 - PubMed
    1. Pharmacol Rev. 1987 Jun;39(2):97-145 - PubMed
    1. J Cell Biochem. 1985;27(4):449-53 - PubMed

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