Sclerosing stromal tumour of the ovary: A case report and the review of literature

Abstract

Sclerosing stromal tumours are rare benign ovarian neoplasms of the sex cord stromal that occur predominantly in the second and third decades of life. To date, 208 cases have been recorded in the literature. Most patients have menstrual irregularities and pelvic pain. Infertility and virilisation have also been described. In this article, histopathological features and differential diagnosis of the benign sclerosing stromal tumour were described together with the literature data. It is imperative to consider the differential diagnosis of a sclerozing stromal tumour of the ovary in a young woman with an ovarian tumour. A combination of morphological, immunohistochemical, radiological and clinical findings is needed in differentiating the tumour from thecoma, fibroma/fibrosarcoma, lipoid tumours and Krukenberg tumour.

Keywords: Ovary; pelvic pain; sclerosing stromal tumours.

Figure 1

A, Macroscopically, the tumour involves the whole ovary and the sectioned surface is mostly solid, white and slightly edematous

Figure 2

Sclerosing stromal tumour histopathologic features. (a) Pseudolobular pattern consisting of a hypercellular and hypocellular area (H and E, ×100). (b) Dual cell populations are seen; spindle cells and round cells (H and E ×200). (c) Hypocellular and hypercellular areas, and a conspicuous hemangiopericytoma-like vascular pattern (H and E, ×100). (d) Tumour cells show cytroplasmic staining for á-inhibin (IHC, ×200)