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. 1989 Oct;78(1):1-6.

Accessory and T cell defects in acquired and inherited hypogammaglobulinaemia

K E Rozynska  1 , G P Spickett, M Millrain, A Edwards, A Bryant, A D Webster, J Farrant
Affiliations

Accessory and T cell defects in acquired and inherited hypogammaglobulinaemia

K E Rozynska et al. Clin Exp Immunol. 1989 Oct.

Abstract

Cellular defects in patients with common variable hypogammaglobulinaemia (CVH) and X-linked agammaglobulinaemia (XLA) have been studied in vitro, using a mitogen-driven system of immunoglobulin production. We have confirmed our previous finding of impaired low-density (dendritic) accessory cell function in CVH and now show that accessory cell function is normal in XLA. We demonstrate that macrophage accessory function is normal in CVH. T cell help for IgM production is also deficient in CVH, and T cell help in XLA is also abnormal for both IgG and IgM. Some XLA patients have excessive T suppressor activity. The contribution of these defects to the clinical states is discussed.

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References

    1. Lancet. 1974 Sep 14;2(7881):609-13 - PubMed
    1. Clin Exp Immunol. 1989 Apr;76(1):19-23 - PubMed
    1. Clin Exp Immunol. 1977 Feb;27(2):208-15 - PubMed
    1. J Immunol. 1978 Apr;120(4):1169-75 - PubMed
    1. J Immunol. 1978 Nov;121(5):2097-105 - PubMed

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