Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Dec;16(12):463.
doi: 10.1007/s11883-014-0463-8.

Ivabradine, coronary heart disease, and heart failure: time for reappraisal

Tomáš Stulc  1 , Richard Ceška
Affiliations
Comment

Ivabradine, coronary heart disease, and heart failure: time for reappraisal

Tomáš Stulc et al. Curr Atheroscler Rep. 2014 Dec.

Abstract

Ivabradine is generally considered to be a safe drug with well-established and substantial benefits. Nevertheless, recently published results from the SIGNIFY trial suggest that ivabradine has rather inconsistent effects on cardiovascular outcomes. In addition, careful examination of all available data from ivabradine trials reveals signals of harm that have not yet been appropriately addressed, including a markedly increased incidence of atrial fibrillation and increased risk of cardiovascular events in patients with heart rates below 70 bpm. These concerns warrant consideration, since they could have implications for the future use of ivabradine.

PubMed Disclaimer

Comment on

References

    1. Eur Heart J. 2013 Aug;34(29):2263-70 - PubMed
    1. Lancet. 2010 Sep 11;376(9744):875-85 - PubMed
    1. N Engl J Med. 2014 Sep 18;371(12):1091-9 - PubMed
    1. Lancet. 2008 Sep 6;372(9641):807-16 - PubMed
    1. Heart. 2014 Oct;100(19):1506-10 - PubMed

LinkOut - more resources