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Observational Study
. 2015 Feb;168(4):571-5.
doi: 10.1111/bjh.13173. Epub 2014 Oct 10.

A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

Matthew J Lawrence  1 , Ahmed Sabra, Gavin Mills, Suresh G Pillai, Wendy Abdullah, Karl Hawkins, Roger H K Morris, Simon J Davidson, Lindsay A D'Silva, Daniel J Curtis, Martin R Brown, John W Weisel, Phylip R Williams, Phillip A Evans
Affiliations
Observational Study

A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

Matthew J Lawrence et al. Br J Haematol. 2015 Feb.

Abstract

This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df ) and clot formation time (TGP ). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.

Keywords: anticoagulation; blood coagulation; haemostasis; venous thrombosis; warfarin.

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