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Review
. 2015 Jan;123(1):6-20.
doi: 10.1289/ehp.1307922. Epub 2014 Oct 10.

Indoor environmental exposures and exacerbation of asthma: an update to the 2000 review by the Institute of Medicine

Watcharoot Kanchongkittiphon  1 , Mark J Mendell, Jonathan M Gaffin, Grace Wang, Wanda Phipatanakul
Affiliations
Review

Indoor environmental exposures and exacerbation of asthma: an update to the 2000 review by the Institute of Medicine

Watcharoot Kanchongkittiphon et al. Environ Health Perspect. 2015 Jan.

Abstract

Background: Previous research has found relationships between specific indoor environmental exposures and exacerbation of asthma.

Objectives: In this review we provide an updated summary of knowledge from the scientific literature on indoor exposures and exacerbation of asthma.

Methods: Peer-reviewed articles published from 2000 to 2013 on indoor exposures and exacerbation of asthma were identified through PubMed, from reference lists, and from authors' files. Articles that focused on modifiable indoor exposures in relation to frequency or severity of exacerbation of asthma were selected for review. Research findings were reviewed and summarized with consideration of the strength of the evidence.

Results: Sixty-nine eligible articles were included. Major changed conclusions include a causal relationship with exacerbation for indoor dampness or dampness-related agents (in children); associations with exacerbation for dampness or dampness-related agents (in adults), endotoxin, and environmental tobacco smoke (in preschool children); and limited or suggestive evidence for association with exacerbation for indoor culturable Penicillium or total fungi, nitrogen dioxide, rodents (nonoccupational), feather/down pillows (protective relative to synthetic bedding), and (regardless of specific sensitization) dust mite, cockroach, dog, and dampness-related agents.

Discussion: This review, incorporating evidence reported since 2000, increases the strength of evidence linking many indoor factors to the exacerbation of asthma. Conclusions should be considered provisional until all available evidence is examined more thoroughly.

Conclusion: Multiple indoor exposures, especially dampness-related agents, merit increased attention to prevent exacerbation of asthma, possibly even in nonsensitized individuals. Additional research to establish causality and evaluate interventions is needed for these and other indoor exposures.

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Conflict of interest statement

Findings, recommendations and views in this paper are those of the authors and not necessarily those of the U.S. Environmental Protection Agency.

The authors declare they have no actual or potential competing financial interests.

References

    1. Arif AA, Shah SM. Association between personal exposure to volatile organic compounds and asthma among US adult population. Int Arch Occup Environ Health. 2007;80:711–719. - PubMed
    1. Atkinson RW, Strachan DP, Anderson HR, Hajat S, Emberlin J. Temporal associations between daily counts of fungal spores and asthma exacerbations. Occup Environ Med. 2006;63:580–590. - PMC - PubMed
    1. Belanger K, Gent JF, Triche EW, Bracken MB, Leaderer BP. Association of indoor nitrogen dioxide exposure with respiratory symptoms in children with asthma. Am J Respir Crit Care Med. 2006;173:297–303. - PMC - PubMed
    1. Belanger K, Holford TR, Gent JF, Hill ME, Kezik JM, Leaderer BP. Household levels of nitrogen dioxide and pediatric asthma severity. Epidemiology. 2013;24:320–330. - PMC - PubMed
    1. Bernstein JA, Bobbitt RC, Levin L, Floyd R, Crandall MS, Shalwitz RA, et al. Health effects of ultraviolet irradiation in asthmatic children’s homes. J Asthma. 2006;43:255–262. - PubMed

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