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Observational Study
. 2015 Jan;70(1):88-91.
doi: 10.1136/thoraxjnl-2014-206041. Epub 2014 Oct 10.

Which intravenous bronchodilators are being administered to children presenting with acute severe wheeze in the UK and Ireland?

I Morris  1 , M D Lyttle  2 , R O'Sullivan  3 , N Sargant  4 , I J M Doull  5 , C V E Powell  6 ; PERUKI network
Collaborators, Affiliations
Observational Study

Which intravenous bronchodilators are being administered to children presenting with acute severe wheeze in the UK and Ireland?

I Morris et al. Thorax. 2015 Jan.

Abstract

During a prospective 10-week assessment period, 3238 children aged 1-16 years presented with acute wheeze to Paediatric Emergency Research in the UK and Ireland centres. 110 (3.3%) received intravenous bronchodilators. Intravenous magnesium sulfate (MgSO4) was used in 67 (60.9%), salbutamol in 61 (55.5%) and aminophylline in 52 (47.3%) of cases. In 35 cases (31.8%), two drugs were used together, and in 18 cases (16.4%), all three drugs were administered. When used sequentially the most common order was salbutamol, then MgSO4, then aminophylline. Overall, 30 different intravenous treatment regimens were used varying in drugs, dose, rate and duration.

Keywords: Asthma; Asthma Guidelines; Asthma Pharmacology; Paediatric asthma.

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