Transdermal therapeutic systems and rate controlled drug delivery
- PMID: 2530425
Transdermal therapeutic systems and rate controlled drug delivery
Abstract
One of the key design features of transdermal therapeutic systems, namely the system rate-control, and its impact on systemic therapy, are reviewed. Specifically, TTS(scopolamine) and TTS(estradiol) are evaluated as examples of the rate-controlled transdermal products. The use of these TTS products has resulted in controlled plasma concentration of drug and reduced side effects by the use of TTS(scopolamine) and more physiologic estradiol to estrone ratio with the transdermal dosage form of estradiol.
Similar articles
-
Pharmacokinetics of weekly transdermal estradiol controlled delivery system in postmenopausal Chinese.Zhongguo Yao Li Xue Bao. 1996 Sep;17(5):407-10. Zhongguo Yao Li Xue Bao. 1996. PMID: 9863160
-
[Therapeutic systems and drug delivery. 3. Transdermal therapeutic systems].Lijec Vjesn. 1990 Jul-Aug;112(7-8):235-43. Lijec Vjesn. 1990. PMID: 2292898 Croatian.
-
[Transdermal therapeutic systems (TTS)].Med Monatsschr Pharm. 1998 Dec;21(12):366-77. Med Monatsschr Pharm. 1998. PMID: 9868897 Review. German. No abstract available.
-
Transdermal delivery of sex steroids for hormone replacement therapy and contraception. A review of principles and practice.J Reprod Med. 2003 Jul;48(7):525-40. J Reprod Med. 2003. PMID: 12953327 Review.
-
Transdermal therapeutic systems--actual state and future developments.Methods Find Exp Clin Pharmacol. 1991 Jun;13(5):343-51. Methods Find Exp Clin Pharmacol. 1991. PMID: 1921571 Review.
Cited by
-
Heating and cooling of the nitroglycerin patch application area modify the plasma level of nitroglycerin.Eur J Clin Pharmacol. 1992;43(6):625-8. doi: 10.1007/BF02284961. Eur J Clin Pharmacol. 1992. PMID: 1493844