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. 2014 Nov 28;588(23):4319-24.
doi: 10.1016/j.febslet.2014.09.040. Epub 2014 Oct 7.

Lumican: a new inhibitor of matrix metalloproteinase-14 activity

Katarzyna Pietraszek  1 , Aurore Chatron-Colliet  1 , Stéphane Brézillon  1 , Corinne Perreau  1 , Anna Jakubiak-Augustyn  2 , Hubert Krotkiewski  2 , François-Xavier Maquart  3 , Yanusz Wegrowski  4
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Free article

Lumican: a new inhibitor of matrix metalloproteinase-14 activity

Katarzyna Pietraszek et al. FEBS Lett. .
Free article

Abstract

We previously showed that lumican regulates MMP-14 expression. The aim of this study was to compare the effect of lumican and decorin on MMP-14 activity. In contrast to decorin, the glycosylated form of lumican was able to significantly decrease MMP-14 activity in B16F1 melanoma cells. Our results suggest that a direct interaction occurs between lumican and MMP-14. Lumican behaves as a competitive inhibitor which leads to a complete blocking of the activity of MMP-14. It binds to the catalytic domain of MMP-14 with moderate affinity (KD∼275 nM). Lumican may protect collagen against MMP-14 proteolysis, thus influencing cell-matrix interaction in tumor progression.

Keywords: Decorin; Lumican; MMP-14; Small leucine-rich proteoglycan.

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