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Review
. 2014 Sep 12:5:434.
doi: 10.3389/fimmu.2014.00434. eCollection 2014.

The role of environmental factors in modulating immune responses in early life

Duncan M MacGillivray  1 , Tobias R Kollmann  1
Affiliations
Review

The role of environmental factors in modulating immune responses in early life

Duncan M MacGillivray et al. Front Immunol. .

Abstract

The concept of immunological memory stipulates that past exposures shape present immune function. These exposures include not only specific antigens impacting adaptive immune memory but also conserved pathogen or danger associated molecular patterns that mold innate immune responses for prolonged periods of time. It should thus not come as a surprise that there is a vast range of external or environmental factors that impact immunity. The importance of environmental factors modulating immunity is most readily recognized in early life, a period of rapidly changing environments. We here summarize available data on the role of environment shaping immune development and from it derive an overarching hypothesis relating the underlying molecular mechanisms and evolutionary principles involved.

Keywords: environment; evolution; immune system; immunologic memory; innate immunity; ontogeny; pediatrics.

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References

    1. Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell (2008) 132(4):631–44 10.1016/j.cell.2008.01.025 - DOI - PMC - PubMed
    1. Cumano A, Dieterlen-Lievre F, Godin I. Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura. Cell (1996) 86(6):907–16 10.1016/S0092-8674(00)80166-X - DOI - PubMed
    1. Cumano A, Ferraz JC, Klaine M, Di Santo JP, Godin I. Intraembryonic, but not yolk sac hematopoietic precursors, isolated before circulation, provide long-term multilineage reconstitution. Immunity (2001) 15(3):477–85 10.1016/S1074-7613(01)00190-X - DOI - PubMed
    1. Tavian M, Robin C, Coulombel L, Péault B. The human embryo, but not its yolk sac, generates lympho-myeloid stem cells: mapping multipotent hematopoietic cell fate in intraembryonic mesoderm. Immunity (2001) 15(3):487–95 10.1016/S1074-7613(01)00193-5 - DOI - PubMed
    1. Zambidis ET, Oberlin E, Tavian M, Péault B. Blood-forming endothelium in human ontogeny: lessons from in utero development and embryonic stem cell culture. Trends Cardiovasc Med (2006) 16(3):95–101 10.1016/j.tcm.2006.01.005 - DOI - PMC - PubMed

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