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. 2014:2014:851676.
doi: 10.1155/2014/851676. Epub 2014 Sep 18.

Serial changes of neointimal tissue after everolimus-eluting stent implantation in porcine coronary artery: an optical coherence tomography analysis

Hoyoun Won  1 , Jung-Sun Kim  2 , Dong-Ho Shin  2 , Byeong-Keuk Kim  2 , Young-Guk Ko  2 , Donghoon Choi  2 , Yangsoo Jang  3 , Myeong-Ki Hong  3
Affiliations

Serial changes of neointimal tissue after everolimus-eluting stent implantation in porcine coronary artery: an optical coherence tomography analysis

Hoyoun Won et al. Biomed Res Int. 2014.

Erratum in

Abstract

Purposes: The serial changes in neointimal tissues were compared between everolimus-eluting stent (EES) and bare-metal stent (BMS) in the porcine coronary artery using optical coherence tomography (OCT).

Methods: Serial (1, 3, and 6 month follow-up after stent implantation) OCT examinations were performed in 15 swine with 15 BMS- and 15 EES-treated lesions in porcine coronary arteries.

Results: In BMS-implanted lesions, neointimal volume decreased from 7.3 mm(3) to 6.9 mm(3) and 6.4 mm(3) at 1, 3, and 6 months follow-up without statistical significance (P = 0.369). At the time points of 1, 3, and 6 months, neointimal tissue appearance was mainly a homogeneous pattern (80.0%, 93.3%, and 100%, resp.), while the other pattern was layered. In contrast, in EES-implanted lesions, neointimal volume significantly increased from 4.8 mm(3) to 9.8 mm(3) between 1 and 3 months but significantly decreased to 8.6 mm(3) between 3 and 6 months (P < 0.001). Between 1 and 3 months, the layered pattern of neointimal tissue increased from 26.7% to 66.7% but decreased to 20.0% between 3 and 6 months.

Conclusions: EES had a biphasic pattern of neointimal amounts that correlated with changes in neointimal morphology.

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Figures

Figure 1
Figure 1
Representative optical coherence tomographic images of neointima. Homogeneous pattern (a) and layered pattern (b).
Figure 2
Figure 2
Serial changes in neointimal volume at the segment with maximal amounts of neointimal hyperplasia at the 1-month follow-up.
Figure 3
Figure 3
Serial changes in neointimal patterns at the segment with maximal amounts of neointimal hyperplasia at the 1-month follow-up. BMS, bare-metal stent; EES, everolimus-eluting stent.
Figure 4
Figure 4
Evolution of serial changes in neointimal patterns in bare-metal stent and everolimus-eluting stent.
Figure 5
Figure 5
Examples of neointimal volume and patterns at the segment with maximal amounts of neointimal hyperplasia at 1, 3, and 6 months following bare-metal stent implantation. NIH, neointimal hyperplasia.
Figure 6
Figure 6
Examples of neointimal volume and patterns at the segment with maximal amounts of neointimal hyperplasia at 1, 3, and 6 months following everolimus-eluting stent implantation. NIH, neointimal hyperplasia.
See this image and copyright information in PMC

References

    1. Kirtane AJ, Gupta A, Iyengar S, et al. Safety and efficacy of drug-eluting and bare metal stents: comprehensive meta-analysis of randomized trials and observational studies. Circulation. 2009;119(25):3198–3206. - PubMed
    1. Marroquin OC, Selzer F, Mulukutla SR, et al. A comparison of bare-metal and drug-eluting stents for off-label indications. The New England Journal of Medicine. 2008;358(4):342–352. - PMC - PubMed
    1. Liistro F, Fineschi M, Angioli P, et al. Effectiveness and safety of sirolimus stent implantation for coronary in-stent restenosis. The true (tuscany registry of sirolimus for unselected in-stent restenosis) registry. Journal of the American College of Cardiology. 2006;48(2):270–275. - PubMed
    1. Murata A, Wallace-Bradley D, Tellez A, et al. Accuracy of optical coherence tomography in the evaluation of neointimal coverage after stent implantation. JACC: Cardiovascular Imaging. 2010;3(1):76–84. - PubMed
    1. Prati F, Regar E, Mintz GS, et al. Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: Physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis. European Heart Journal. 2010;31(4):401–415. - PubMed

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