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Review
. 2014 Dec;95(6):495-505.
doi: 10.1007/s00223-014-9917-9. Epub 2014 Oct 14.

Osteoarthritis pathogenesis: a review of molecular mechanisms

Bingjiang Xia  1 , Di Chen, Jushi Zhang, Songfeng Hu, Hongting Jin, Peijian Tong
Affiliations
Review

Osteoarthritis pathogenesis: a review of molecular mechanisms

Bingjiang Xia et al. Calcif Tissue Int. 2014 Dec.

Abstract

Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal cause of impaired mobility in the elderly. Because the precise molecular mechanisms which are involved in the degradation of cartilage matrix and development of OA are poorly understood and there are currently no effective interventions to decelerate the progression of OA or retard the irreversible degradation of cartilage except for total joint replacement surgery. In this paper, the important molecular mechanisms related to OA pathogenesis will be summarized and new insights into potential molecular targets for the prevention and treatment of OA will be provided.

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