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. 1989 Oct;9(10):4550-5.
doi: 10.1128/mcb.9.10.4550-4555.1989.

Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA

A Y Tsai  1 , M Streuli, H Saito
Affiliations

Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA

A Y Tsai et al. Mol Cell Biol. 1989 Oct.

Abstract

By alternative splicing, exons 4, 5, and 6 of the human leukocyte common antigen (LCA) gene are included in B-cell mRNA but excluded from thymocyte mRNA. A mini-LCA gene that contains only LCA exons 2, 6, and 8 faithfully reproduces this tissue-specific alternative splicing in mouse B and thymocyte cell lines. Elimination of almost all of the intron sequences associated with exon 6 had no effect on the alternative splicing, while linker-scanning analysis showed that a significant length of the exon 6 sequence is essential for alternative splicing.

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References

    1. J Exp Med. 1980 Oct 1;152(4):842-52 - PubMed
    1. J Immunol. 1988 Apr 1;140(7):2171-8 - PubMed
    1. Nature. 1983 Jan 6;301(5895):38-43 - PubMed
    1. J Immunol. 1985 Mar;134(3):1508-15 - PubMed
    1. J Immunol. 1985 Jun;134(6):3762-9 - PubMed

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