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. 2014 Dec;135(3):423-7.
doi: 10.1016/j.ygyno.2014.10.005. Epub 2014 Oct 12.

Effect of tubal sterilization technique on risk of serous epithelial ovarian and primary peritoneal carcinoma

Collette R Lessard-Anderson  1 , Kathryn S Handlogten  2 , Rochelle J Molitor  3 , Sean C Dowdy  4 , William A Cliby  5 , Amy L Weaver  6 , Jennifer St Sauver  7 , Jamie N Bakkum-Gamez  8
Affiliations

Effect of tubal sterilization technique on risk of serous epithelial ovarian and primary peritoneal carcinoma

Collette R Lessard-Anderson et al. Gynecol Oncol. 2014 Dec.

Abstract

Objective: To determine the effect of excisional tubal sterilization on subsequent development of serous epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC).

Methods: We performed a population-based, nested case-control study using the Rochester Epidemiology Project. We identified all patients with a diagnosis of serous EOC or PPC from 1966 through 2009. Each case was age-matched to 2 controls without either diagnosis. Odds ratios (ORs) and corresponding 95% CIs were estimated from conditional logistic regression models. Models were adjusted for prior hysterectomy, prior salpingo-oophorectomy, oral contraceptive use, endometriosis, infertility, gravidity, and parity.

Results: In total, we identified 194 cases of serous EOC and PPC during the study period and matched them with 388 controls (mean [SD] age, 61.4 [15.2] years). Fourteen cases (7.2%) and 46 controls (11.9%) had undergone tubal sterilization. Adjusted risk of serous EOC or PPC was slightly lower after any tubal sterilization (OR, 0.59 [95% CI, 0.29-1.17]; P=.13). The rate of excisional tubal sterilization was lower in cases than controls (2.6% vs 6.4%). Adjusted risk of serous EOC and PPC was decreased by 64% after excisional tubal sterilization (OR, 0.36 [95% CI, 0.13-1.02]; P=.054) compared with those without sterilization or with nonexcisional tubal sterilization.

Conclusions: We present a population-based investigation of the effects of excisional tubal sterilization on the risk of serous EOC and PPC. Excisional methods may confer greater risk reduction than other sterilization methods.

Keywords: Fimbriectomy; Salpingectomy; Serous ovarian cancer; Serous primary peritoneal cancer; Tubal sterilization.

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Conflict of interest statement

The authors report no conflict of interest.

References

    1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014 Jan;64(1):9–29. Epub 2014 Jan 7. - PubMed
    1. Kim J, Coffey DM, Creighton CJ, Yu Z, Hawkins SM, Matzuk MM. High-grade serous ovarian cancer arises from fallopian tube in a mouse model. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3921–6. Epub 2012 Feb 13. - PMC - PubMed
    1. Crum CP, Drapkin R, Kindelberger D, Medeiros F, Miron A, Lee Y. Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer. Clin Med Res. 2007 Mar;5(1):35–44. - PMC - PubMed
    1. Mavaddat N, Barrowdale D, Andrulis IL, Domchek SM, Eccles D, Nevanlinna H, et al. Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) Cancer Epidemiol Biomarkers Prev. 2012 Jan;21(1):134–47. Epub 2011 Dec 5. - PMC - PubMed
    1. Pennington KP, Swisher EM. Hereditary ovarian cancer: beyond the usual suspects. Gynecol Oncol. 2012 Feb;124(2):347–53. - PubMed

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