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Review
. 2014 Dec;16(12):1002-12.
doi: 10.1016/j.micinf.2014.09.010. Epub 2014 Oct 12.

Intracellular sensing of viral DNA by the innate immune system

Daniel S Mansur  1 , Geoffrey L Smith  2 , Brian J Ferguson  3
Affiliations
Free article
Review

Intracellular sensing of viral DNA by the innate immune system

Daniel S Mansur et al. Microbes Infect. 2014 Dec.
Free article

Abstract

Recent years have seen a great advance in knowledge of how a host senses infection. Nucleic acids, as a common denominator to all pathogens, are at the centre of several of the sensing pathways, especially those involved with the recognition of viruses. In this review we discuss the current knowledge on how intracellular DNA is sensed by the mammalian host.

Keywords: Autoinflammation; DNA sensing; Immune evasion; Type one interferon; Vaccines; Virus recognition.

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