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. 2014 Oct;198(2):435-7.
doi: 10.1534/genetics.114.169128.

Yeast systems biology: our best shot at modeling a cell

Charles Boone  1
Affiliations

Yeast systems biology: our best shot at modeling a cell

Charles Boone. Genetics. 2014 Oct.

Abstract

THE Genetics Society of America's Edward Novitski Prize recognizes an extraordinary level of creativity and intellectual ingenuity in the solution of significant problems in genetics research. The 2014 recipient, Charles Boone, has risen to the top of the emergent discipline of postgenome systems biology by focusing on the global mapping of genetic interaction networks. Boone invented the synthetic genetic array (SGA) technology, which provides an automated method to cross thousands of strains carrying precise mutations and map large-scale yeast genetic interactions. These network maps offer researchers a functional wiring diagram of the cell, which clusters genes into specific pathways and reveals functional connections.

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Charles Boone
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References

    1. Ashburner M., Ball C. A., Blake J. A., Botstein D., Butler H., et al. , 2000. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25: 25–29 - PMC - PubMed
    1. Baryshnikova A., Costanzo M., Kim Y., Ding H., Koh J., et al. , 2010. Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nat. Methods 7: 1017–1024 - PMC - PubMed
    1. Bloom J. S., Ehrenreich I. M., Loo W. T., Lite T.-L. V., Kruglyak L., 2013. Finding the sources of missing heritability in a yeast cross. Nature 494: 234–237 - PMC - PubMed
    1. Botstein D., Fink G. R., 2011. Yeast: an experimental organism for 21st Century biology. Genetics 189: 695–704 - PMC - PubMed
    1. Cherry J., 1998. SGD: Saccharomyces Genome Database. Nucleic Acids Res. 26: 73–79 - PMC - PubMed

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