Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Aug 8;15(3):156-60.
doi: 10.5152/jtgga.2014.13068. eCollection 2014.

Reproducibility of a time-lapse embryo selection model based on morphokinetic data in a sequential culture media setting

Ender Yalçınkaya  1 , Elif G Ergin  1 , Eray Calışkan  1 , Zeynep Oztel  1 , Alev Ozay  1 , Hakan Ozörnek  1
Affiliations

Reproducibility of a time-lapse embryo selection model based on morphokinetic data in a sequential culture media setting

Ender Yalçınkaya et al. J Turk Ger Gynecol Assoc. .

Abstract

Objective: To compare the outcomes of embryos that were given a dynamic score based on a preconstructed embryo scoring model and to analyze whether this model complies with our data.

Material and methods: A total of 910 transferred embryos with known implantation data were retrospectively analyzed in this study. All of the embryos were given a dynamic score based on the preconstructed hierarchical embryo scoring model.

Results: The highest pregnancy rate was seen in groups C+ and A- (48.2% for each), and the lowest was observed in Group E (19.7%). When implantation and clinical pregnancy rates were compared between groups, it was found that the highest and statistically significant implantation and clinical pregnancy rates were seen in group C+ (32.7% for each, p=0.000). They were dropped down to 29.4% in Group A-.

Conclusion: The outcomes of the embryos based on the dynamic score do not comply with the results of the preconstructed model. Each IVF laboratory is unique based on its practice. Therefore, we suggest that each IVF laboratory should determine its own embryo selection criteria based on its own data instead of using a preconstructed model.

Keywords: Preconstructed model; dynamic score; pregnancy rate.

PubMed Disclaimer

Figures

Figure 1
Figure 1
a, b. Figures above are two examples of transfer embryos at day 3. The photographs were captured by the camera system in time-lapse system. Embryo morphology looks similar; but dynamic scores based on embryo morphokinetics are different. Embryo with a dynamic score of A+ (a), Embryo with a dynamic score of C+ based on Meseguer’s scoring model (b)
Figure 2
Figure 2
Comparison of the clinical outcomes of the embryos with different dynamic scores (p<0.05)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Seli E, Sakkas D, Scott R, Kwok SC, Rosendahl SM, Burns DH. Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertil Steril. 2007;88:1350–7. - PubMed
    1. Sakkas D, Gardner DK. Noninvasive methods to assess embryo quality. Curr Opin Obstet Gynecol. 2005;17:283–8. - PubMed
    1. Katz-Jaffe MG, Gardner DK. Symposium: Innovative techniques in human embryo viability assessment. Can proteomics help to change the future of human assisted conception? Reprod Biomed Online. 2008;17:497–501. - PubMed
    1. Wong CC, Loewke KE, Bossert NL, Behr B, De Jonge CJ, Baer TM, Reijo Pera RA. Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Nat Biotechnol. 2010;28:1115–21. - PubMed
    1. Wong C, Chen AA, Behr B, Shen S. Time-lapse microscopy and image analysis in basic and clinical embryo development research. Reprod Biomed Online. 2013;26:120–9. - PubMed

LinkOut - more resources